A New Level of Single-Cell Insight is on the Horizon

A New Level of Single-Cell Insight is on the Horizon.

Leading researchers are already exploring the power of measuring targeted DNA and RNA expression together—cell by cell. Mission Bio is developing a solution to make this capability more accessible for you, enabling deeper understanding of clonal architecture, gene function, and therapeutic response in oncology and cell and gene therapy research.

Why Analyze DNA and RNA Together in a Single Cell?

Traditional methods only capture averages across populations of cells—masking critical biological diversity. This single-cell assay enables:

Targeted mutation detection (SNVs, indels, CNVs, translocations)
Targeted gene expression profiling from the same individual cells
Connections between genotype and gene activity

For Oncology, Hematologic Disease, and Cell Therapy Applications

For oncology and blood cancers:

Functionally validate mutational profile
Reveal genotypic and phenotypic drivers of relapse to inform next-gen therapies, rational combinations, and biomarker-driven strategies
Reveal phenotypes and clonal dynamics behind T-cell dysfunction to enable design of next-gen CARs

For engineered cell therapies

Establish a comprehensive understanding of clonotype identity based on their genotype and RNA expression to assess the safety and efficacy of your drug product
Monitor exhaustion, persistence, and potency markers
Assess how gene edits drive changes in cellular behavior

Resources: Explore How Others Are Using Targeted DNA + RNA Single-Cell Analysis

Curious how integrated single-cell data is shaping discovery and development? Check out these resources:

Review Customer Publications

Functional phenotyping of genomic variants using multiomic scDNA-scRNA-seq

Genotype-to-phenotype mapping of somatic clonal mosaicism via single-cell co-capture of DNA mutations and mRNA transcripts

Coming Soon: Tapestri Single-Cell Targeted DNA + RNA Expression Assay

Learn more in this Blog Post

Join the Waitlist!

Fill out the form to schedule time with a Mission Bio single-cell expert. Let’s explore how targeted DNA + RNA can advance your next discovery or therapeutic program. We’ll contact you when more information is available.